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drd1 floxed mice  (Jackson Laboratory)

 
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    Jackson Laboratory drd1 floxed mice
    a Experimental scheme of the experiment to monitor dendritic spine morphology of striatal D1 and D2 MSN in the DLS after chemogenetic modulation of the SNc in astrocytic Megf10 conditional knock-down. b Representative confocal z-stack images showing dendritic spines of D1 MSN ( <t>Drd1a-Cre</t> ) and D2 MSN ( Adora2a-Cre ) (White: eGFP, t: thin spine, s: stubby spine, m: mushroom spine). Scale bar, 10 μm. c Quantification of the dendritic spine density in D1 MSN (Scramble; Vehicle: n = 7 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 8 mice, CNO: n = 8 mice; one-way ANOVA). d Quantification of the dendritic spine density in D2 MSN. (Scramble; Vehicle: n = 6 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 7 mice, CNO: n = 7 mice; one-way ANOVA). Data were presented as mean values ± SEM.
    Drd1 Floxed Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/drd1+floxed+mice/pmc12929717-233-5-17?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    drd1 floxed mice - by Bioz Stars, 2026-07
    86/100 stars

    Images

    1) Product Images from "Motor learning and dopamine-dependent striatal synaptic plasticity are controlled by astrocytic MEGF10"

    Article Title: Motor learning and dopamine-dependent striatal synaptic plasticity are controlled by astrocytic MEGF10

    Journal: Nature Communications

    doi: 10.1038/s41467-026-69129-1

    a Experimental scheme of the experiment to monitor dendritic spine morphology of striatal D1 and D2 MSN in the DLS after chemogenetic modulation of the SNc in astrocytic Megf10 conditional knock-down. b Representative confocal z-stack images showing dendritic spines of D1 MSN ( Drd1a-Cre ) and D2 MSN ( Adora2a-Cre ) (White: eGFP, t: thin spine, s: stubby spine, m: mushroom spine). Scale bar, 10 μm. c Quantification of the dendritic spine density in D1 MSN (Scramble; Vehicle: n = 7 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 8 mice, CNO: n = 8 mice; one-way ANOVA). d Quantification of the dendritic spine density in D2 MSN. (Scramble; Vehicle: n = 6 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 7 mice, CNO: n = 7 mice; one-way ANOVA). Data were presented as mean values ± SEM.
    Figure Legend Snippet: a Experimental scheme of the experiment to monitor dendritic spine morphology of striatal D1 and D2 MSN in the DLS after chemogenetic modulation of the SNc in astrocytic Megf10 conditional knock-down. b Representative confocal z-stack images showing dendritic spines of D1 MSN ( Drd1a-Cre ) and D2 MSN ( Adora2a-Cre ) (White: eGFP, t: thin spine, s: stubby spine, m: mushroom spine). Scale bar, 10 μm. c Quantification of the dendritic spine density in D1 MSN (Scramble; Vehicle: n = 7 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 8 mice, CNO: n = 8 mice; one-way ANOVA). d Quantification of the dendritic spine density in D2 MSN. (Scramble; Vehicle: n = 6 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 7 mice, CNO: n = 7 mice; one-way ANOVA). Data were presented as mean values ± SEM.

    Techniques Used: Knockdown



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    drd1 floxed mice  (Jackson Laboratory)
    86
    Jackson Laboratory drd1 floxed mice
    a Experimental scheme of the experiment to monitor dendritic spine morphology of striatal D1 and D2 MSN in the DLS after chemogenetic modulation of the SNc in astrocytic Megf10 conditional knock-down. b Representative confocal z-stack images showing dendritic spines of D1 MSN ( <t>Drd1a-Cre</t> ) and D2 MSN ( Adora2a-Cre ) (White: eGFP, t: thin spine, s: stubby spine, m: mushroom spine). Scale bar, 10 μm. c Quantification of the dendritic spine density in D1 MSN (Scramble; Vehicle: n = 7 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 8 mice, CNO: n = 8 mice; one-way ANOVA). d Quantification of the dendritic spine density in D2 MSN. (Scramble; Vehicle: n = 6 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 7 mice, CNO: n = 7 mice; one-way ANOVA). Data were presented as mean values ± SEM.
    Drd1 Floxed Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/drd1+floxed+mice/pmc12929717-233-5-17?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    drd1 floxed mice - by Bioz Stars, 2026-07
    86/100 stars
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    drd1 flox/flox mice  (Jackson Laboratory)
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    Jackson Laboratory drd1 flox/flox mice
    a Experimental scheme. Propranolol was bilaterally infused in the mPFC 20 minutes before CFC. b Representative image of the cannula above the mPFC. Scale bar: 1 mm. c The statistical graphs for freezing levels during memory tests. d Experimental scheme. AAV-mCaMKIIα-eGFP-P2A-iCre was injected in the mPFC of Adrb1 flox/flox , Adrb1 +/+ , Adrb2 flox/flox , Adrb2 +/+ , <t>Drd1</t> flox/flox and Drd1 +/+ mice. Behavioral tests were performed 1 month after virus injection. e , f , h , i , k , l Representative images and statistical graphs of Adrb1 , Adrb2 , and Drd1 mRNA expression in the mPFC. Scale bar: 100 µm. g , j , m The statistical graphs for freezing levels during memory tests. n Experimental scheme. AAV-mCaMKIIα-eGFP-P2A-iCre was injected in the mPFC of Adrb1 flox/flox and Adrb1 +/+ mice, and AAV-TH-Cre mixed with AAV-EF1α-DIO-hChR2-mCherry was injected in the LC. Optical fibers were implanted above the mPFC. Optogenetic stimulation (473 nm, 10 mW, 20 Hz, 1 s duration in every 10 s) was delivered during CFC. o Representative images of ChR2-mCherry and eGFP-Cre expression and optical fiber tip. Scale bar: LC: 200 µm; mPFC: 500 µm. p The statistical graphs for freezing levels during memory tests. * p < 0.05, *** p < 0.001 vs indicated group.
    Drd1 Flox/Flox Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/drd1+floxed+mice/pmc09734098-224-22-29?v=Jackson+Laboratory
    Average 90 stars, based on 1 article reviews
    drd1 flox/flox mice - by Bioz Stars, 2026-07
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    Image Search Results


    a Experimental scheme of the experiment to monitor dendritic spine morphology of striatal D1 and D2 MSN in the DLS after chemogenetic modulation of the SNc in astrocytic Megf10 conditional knock-down. b Representative confocal z-stack images showing dendritic spines of D1 MSN ( Drd1a-Cre ) and D2 MSN ( Adora2a-Cre ) (White: eGFP, t: thin spine, s: stubby spine, m: mushroom spine). Scale bar, 10 μm. c Quantification of the dendritic spine density in D1 MSN (Scramble; Vehicle: n = 7 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 8 mice, CNO: n = 8 mice; one-way ANOVA). d Quantification of the dendritic spine density in D2 MSN. (Scramble; Vehicle: n = 6 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 7 mice, CNO: n = 7 mice; one-way ANOVA). Data were presented as mean values ± SEM.

    Journal: Nature Communications

    Article Title: Motor learning and dopamine-dependent striatal synaptic plasticity are controlled by astrocytic MEGF10

    doi: 10.1038/s41467-026-69129-1

    Figure Lengend Snippet: a Experimental scheme of the experiment to monitor dendritic spine morphology of striatal D1 and D2 MSN in the DLS after chemogenetic modulation of the SNc in astrocytic Megf10 conditional knock-down. b Representative confocal z-stack images showing dendritic spines of D1 MSN ( Drd1a-Cre ) and D2 MSN ( Adora2a-Cre ) (White: eGFP, t: thin spine, s: stubby spine, m: mushroom spine). Scale bar, 10 μm. c Quantification of the dendritic spine density in D1 MSN (Scramble; Vehicle: n = 7 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 8 mice, CNO: n = 8 mice; one-way ANOVA). d Quantification of the dendritic spine density in D2 MSN. (Scramble; Vehicle: n = 6 mice, CNO: n = 7 mice, sh Megf10 ; Vehicle: n = 7 mice, CNO: n = 7 mice; one-way ANOVA). Data were presented as mean values ± SEM.

    Article Snippet: Aldh1l1-CreERT2 mice (FVB-Tg( Aldh1l1-cre/ERT2 )1Khakh/J), Drd1 floxed mice (Drd1tm2.1Stl/J), and Drd2 floxed mice (B6.129S4(FVB)-Drd2tm1.1Mrub/J) were purchased from the Jackson Laboratory.

    Techniques: Knockdown

    a Experimental scheme. Propranolol was bilaterally infused in the mPFC 20 minutes before CFC. b Representative image of the cannula above the mPFC. Scale bar: 1 mm. c The statistical graphs for freezing levels during memory tests. d Experimental scheme. AAV-mCaMKIIα-eGFP-P2A-iCre was injected in the mPFC of Adrb1 flox/flox , Adrb1 +/+ , Adrb2 flox/flox , Adrb2 +/+ , Drd1 flox/flox and Drd1 +/+ mice. Behavioral tests were performed 1 month after virus injection. e , f , h , i , k , l Representative images and statistical graphs of Adrb1 , Adrb2 , and Drd1 mRNA expression in the mPFC. Scale bar: 100 µm. g , j , m The statistical graphs for freezing levels during memory tests. n Experimental scheme. AAV-mCaMKIIα-eGFP-P2A-iCre was injected in the mPFC of Adrb1 flox/flox and Adrb1 +/+ mice, and AAV-TH-Cre mixed with AAV-EF1α-DIO-hChR2-mCherry was injected in the LC. Optical fibers were implanted above the mPFC. Optogenetic stimulation (473 nm, 10 mW, 20 Hz, 1 s duration in every 10 s) was delivered during CFC. o Representative images of ChR2-mCherry and eGFP-Cre expression and optical fiber tip. Scale bar: LC: 200 µm; mPFC: 500 µm. p The statistical graphs for freezing levels during memory tests. * p < 0.05, *** p < 0.001 vs indicated group.

    Journal: Nature Communications

    Article Title: Noradrenergic signaling mediates cortical early tagging and storage of remote memory

    doi: 10.1038/s41467-022-35342-x

    Figure Lengend Snippet: a Experimental scheme. Propranolol was bilaterally infused in the mPFC 20 minutes before CFC. b Representative image of the cannula above the mPFC. Scale bar: 1 mm. c The statistical graphs for freezing levels during memory tests. d Experimental scheme. AAV-mCaMKIIα-eGFP-P2A-iCre was injected in the mPFC of Adrb1 flox/flox , Adrb1 +/+ , Adrb2 flox/flox , Adrb2 +/+ , Drd1 flox/flox and Drd1 +/+ mice. Behavioral tests were performed 1 month after virus injection. e , f , h , i , k , l Representative images and statistical graphs of Adrb1 , Adrb2 , and Drd1 mRNA expression in the mPFC. Scale bar: 100 µm. g , j , m The statistical graphs for freezing levels during memory tests. n Experimental scheme. AAV-mCaMKIIα-eGFP-P2A-iCre was injected in the mPFC of Adrb1 flox/flox and Adrb1 +/+ mice, and AAV-TH-Cre mixed with AAV-EF1α-DIO-hChR2-mCherry was injected in the LC. Optical fibers were implanted above the mPFC. Optogenetic stimulation (473 nm, 10 mW, 20 Hz, 1 s duration in every 10 s) was delivered during CFC. o Representative images of ChR2-mCherry and eGFP-Cre expression and optical fiber tip. Scale bar: LC: 200 µm; mPFC: 500 µm. p The statistical graphs for freezing levels during memory tests. * p < 0.05, *** p < 0.001 vs indicated group.

    Article Snippet: TH-Cre mice (#008601), R26 AI14 (AI14) mice (#007914), Fos 2A-iCreER mice (#030323, TRAP2 ), Arc CreER mice (#021881), c-fos-tTA mice (#018306) and Drd1 flox/flox mice (#025700) were purchased from The Jackson Laboratory (CA, USA).

    Techniques: Injection, Virus, Expressing